| Modification (moteur) | Portes | Puissance (CV) | Coupé de type | Places | Début (année) | Fin (année) |
|---|---|---|---|---|---|---|
| S 550 (388 Hp) | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 450 (340 Hp) | 4 | 340 | Sedan | 5 | 2005 | 2009 |
| S 65 AMG (612 Hp) | 4 | 612 | Sedan | 4 | 2005 | 2009 |
| S 600 Lang (517 Hp) | 4 | 517 | Sedan | 5 | 2005 | 2009 |
| S 500 (388 Hp) | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 450 4Matic (340 Hp) | 4 | 340 | Sedan | 5 | 2005 | 2009 |
| S 500 Lang (388 Hp) | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 350 Lang (272 Hp) | 4 | 272 | Sedan | 4 | 2005 | 2009 |
| S 500 4Matic (388 Hp) Long | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 500 4Matic (388 Hp) | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 450 4Matic (340 Hp) Long | 4 | 340 | Sedan | 5 | 2005 | 2009 |
| S 550 Lang (388 Hp) | 4 | 388 | Sedan | 5 | 2005 | 2009 |
| S 450 (340 Hp) Long | 4 | 340 | Sedan | 5 | 2005 | 2009 |
| S 63 AMG (525HP) Long | 4 | 525 | Sedan | 4 | 2005 | 2009 |
| S 350 4Matic (272 Hp) 7G-Tronic Long | 4 | 272 | Sedan | 5 | 2005 | 2009 |
| S 350 (272 Hp) 7G-Tronic | 4 | 272 | Sedan | 5 | 2005 | 2009 |
| S 350 4Matic (272 Hp) 7G-Tronic | 4 | 272 | Sedan | 5 | 2005 | 2009 |